| 叶酰多聚谷氨酸合成酶与肿瘤耐药 |
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| 引用本文： | 孙利,沈佐君. 叶酰多聚谷氨酸合成酶与肿瘤耐药[J]. 生命的化学, 2010, 0(2) |
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| 作者姓名： | 孙利 沈佐君 |
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| 作者单位： | 安徽医科大学附属省立医院;安徽省立医院安徽省临床检验中心; |
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| 基金项目： | 国家自然科学基金项目(编号30672011); 安徽省自然科学基金资助项目(编号050430902); 安徽省人才开发资金资助项目(编号2005Z040)资助 |
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| 摘 要： | 叶酰多聚谷氨酸合成酶(folyl-polyglutamate synthetase,FPGS)是近几年来研究比较多的肿瘤耐药靶酶之一。随着人们对其在基因组学和蛋白组学研究的逐渐深入,涉及FPGS(分胞浆型cFPGS和线粒体型mFPGS两种异构体)与肿瘤耐药的研究也越来越多。本文就FPGS结构、功能、生化特点及其与肿瘤耐药关系作一综述,并探讨其在临床的应用前景和意义。
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| 关 键 词： | 叶酰多聚谷氨酸合成酶 肿瘤 抗药性 |
Folyl-polyglutamate synthetase and tumor resistance |
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| Sun Li,Zuo-Jun Shen Anhui Provincial Center for Clinical Laboratories,Anhui Provincial Hospital,The Affiliated Provincial Hospital of Anhui Medical University,Hefei ,China. Folyl-polyglutamate synthetase and tumor resistance[J]. Chemistry of Life, 2010, 0(2) |
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| Authors: | Sun Li Zuo-Jun Shen Anhui Provincial Center for Clinical Laboratories Anhui Provincial Hospital The Affiliated Provincial Hospital of Anhui Medical University Hefei China |
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| Affiliation: | Sun Li,Zuo-Jun Shen Anhui Provincial Center for Clinical Laboratories,Anhui Provincial Hospital,The Affiliated Provincial Hospital of Anhui Medical University,Hefei 230001,China |
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| Abstract: | Folyl-polyglutamate synthetase (FPGS) has been studied as one of the important target enzymes of tumor resistance in recent years.With the genomics and proteomics of FPGS studied gradually,more and more studies focused on FPGS (cytoplasm and mitochondria FPGS) and tumor resistance.This paper summarized the structure,function,biochemical charac- teristics of FPGS and its relationship with tumor resistance,which explored its application and significance in clinical. |
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| Keywords: | folyl-polyglutamate synthetase tumor drug resistance |
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