Changes in malate dehydrogenase isoenzymes during differentiation of rabbit bone marrow erythroid cells |
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| Affiliation: | Department of Biochemistry, University of London King''s College, Strand, London WC2R 2LS U.K. |
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| Abstract: | - 1.l. Malate dehydrogenase activity was assayed in rabbit bone marrow erythroid cells which had been separated by velocity sedimentation into six fractions corresponding to different stages of development.
- 2.2. During differentiation enzyme activity decreased 10-fold and one of the two isoenzymes present in immature cells was lost.
- 3.3. The most extensive change occurred in orthochromatic erythroblasts immediately after condensation of the nucleus.
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