The synthesis and content of neurotransmitters and their effect on cyclic nucleotide accumulation in the central nervous system of Manduca sexta |
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| Affiliation: | 1. Bioinformatics Centre, Savitribai Phule Pune University (formerly University of Pune), Pune 411007, Maharashtra, India;2. Department of Statistics, Savitribai Phule Pune University (formerly University of Pune), Pune 411007, Maharashtra, India;1. Department of Forensic Medicine, Fattouma Bourguiba University Hospital, June 1st 1995 Street, 5000, Monastir, Tunisia;2. Department of Forensic Medicine, Ibn El Jazzar University Hospital, Kairouan, Tunisia;3. Department of Pathological Anatomy and Cytology, Fattouma Bourguiba University Hospital, June 1st 1995 Street, 5000, Monastir, Tunisia |
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| Abstract: | In this study the ability of the intact nerve cord of Manduca sexta to synthesize 5-hydroxytryptamine (serotonin) and acetylcholine from labelled precursors is shown. The endogenous levels of amino acids in haemolymph and nervous tissue and the levels of dopamine, norepinephrine, 5-hydroxytryptophan and 5-hydroxytryptamine are presented.The accumulation of cyclic AMP and cyclic GMP in nerve cords from Manduca sexta was investigated after in vitro incubation in solutions containing putative neurotransmitters. Basal cyclic AMP levels were in agreement with results of other workers using insect systems. Serotonin elevated cyclic AMP levels. Acetylcholine and the amino acids aspartate, glutamate, glycine and γ-aminobutyrate, elevated cyclic GMP levels. These results support roles for serotonin and acetylcholine in neuronal function mediated by cyclic AMP and cyclic GMP, respectively. |
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