Drugs,leads, and drug-likeness: an analysis of some recently launched drugs |
| |
| Authors: | Proudfoot John R |
| |
| Affiliation: | Boehringer Ingelheim Pharmaceuticals Inc., Department of Medicinal Chemistry, 900 Ridgebury Road, PO Box 368, Ridgefield, CT 06877, USA. jrproudfo@rdg.boehringer-ingelheim.com |
| |
| Abstract: | An analysis of the origins of recently launched drugs reveals that most were derived by modification of known drug structures or from lead structures obtained from the scientific literature. High-throughput screening did not have a significant impact on the derivation of these drugs. The drug structures are very closely related to their leads. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
