Synthesis of modified nucleotide building blocks containing electrophilic groups in the 2'-position |
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| Authors: | Kachalova A V Zatsepin T S Romanova E A Stetsenko D A Gait M J Oretskaya T S |
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| Affiliation: | Chemistry Department and Belozersky Institute of Physical Chemical Biology, Moscow State University, Russia. |
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| Abstract: | Chemical syntheses of 2'-O-(allyloxycarbonyl)methyladenosine, 2'-O-(methoxycarbonyl)methyladenosine and 2'-O-(2,3-dibenzoyloxy)propyluridine 3'-2-cyanoethyl-N,N-diisopropyl phosphoramidite building blocks are described. These monomers were used successfully to incorporate carboxylic acid, 1,2-diol and aldehyde functionalities into synthetic oligonucleotides. |
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