New efficient synthesis of thymidine cyclic 3',5'-phosphorofluoridate and its sulfur analogue via the phosphoroamidite route |
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| Authors: | Dabkowski W Tworowska I Michalski J Cramer F |
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| Institution: | Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Lód?. |
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| Abstract: | We describe the convenient synthesis of thymidine cyclic 3', 5'-phosphorofluoridate 6, which is superior to that previously reported. Our procedure is based on a sequence of reactions utilizing 3 as the key substrate. Similar sequence of reaction leads to the sulfur analogues of 6 the thymidine cyclic 3',5'-phosphorofluoridothioate 7. |
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