Optimization of codon composition and regulatory elements for expression of human insulin like growth factor-1 in transgenic chloroplasts and evaluation of structural identity and function |
| |
| Authors: | Henry Daniell Gricel Ruiz Bela Denes Laurence Sandberg William Langridge |
| |
| Institution: | (1) Department of Molecular Biology and Microbiology, University of Central Florida, College of Medicine, Biomolecular Science Building, Room 336, Orlando, FL 32816-2364, USA;(2) Center for Health Disparities and Molecular Medicine, 161 Mortensen Hall, Loma Linda University, Loma Linda, CA 92350, USA;(3) Department of Biochemistry, Loma Linda University, Loma Linda, CA 92350, USA |
| |
| Abstract: | Background Transgenic chloroplasts are potential bioreactors for recombinant protein production, especially for achievement of high levels
of protein expression and proper folding. Production of therapeutic proteins in leaves provides transgene containment by elimination
of reproductive structures. Therefore, in this study, human Insulin like Growth Factor-1 is expressed in transgenic chloroplasts
for evaluation of structural identity and function. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
