Complex Inhibition of [3H]Imipramine Binding by Serotonin and Nontricyclic Serotonin Uptake Blockers |
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Authors: | M Sette M S Briley S Z Langer |
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Institution: | Department of Biology, LERS Synthélabo, Paris, France |
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Abstract: | Tricyclic antidepressant drugs inhibit 3H]imipramine binding to the rat brain cortex in a competitive manner, giving linear Hofstee plots and Hill coefficients of approximately 1.0. Serotonin, the only neurotransmitter to inhibit 3H]imipramine binding, does so in a complex manner, exhibiting a Hill coefficient of 0.40-0.50. Nontricyclic inhibitors of serotonin uptake such as fluoxetine, paroxetine, norzimelidine, and citalopram inhibit 3H]imipramine binding in the same complex manner as serotonin. These results are interpreted as suggesting that 3H]imipramine binds to a site associated with the serotonin uptake system but different from either the substrate recognition site for serotonin or the site of action of the nontricyclic inhibitors of neuronal uptake of serotonin. |
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Keywords: | [3H]Imipramine binding Complex inhibition of binding Serotonin uptake Tricyclic and nontricyclic antidepressants Serotonin |
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