Sensitive gas chromatographic determination of trifluoperazine in human plasma |
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Authors: | T.J. Gillespie I. Glenn Sipes |
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Affiliation: | Toxicology Program, University of Arizona, Tucson, AZ 85724 U.S.A.;Department of Anesthesiology, Arizona Health Sciences Center, Tucson, AZ 85724 U.S.A. |
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Abstract: | Plasma trifluoperazine levels of patients taking a single 20-mg dose of trifluoperazine were measured by a sensitive and linear method. The low detection limit of 0.1 ng/ml plasma was obtained through use of a highly sensitive nitrogen—phosphorus detector combined with an efficient extraction method. Recovery of trifluoperazine added to human plasma was 96%. Data are presented on the stability of trifluoperazine in refrigerated human plasma. |
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