Fully automated high-performance liquid chromatography : A new chromatograph for pharmacokinetic drug monitoring by direct injection of body fluids |
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Authors: | Willy Roth Klaus Beschke Rolf Jauch Arno Zimmer F.W. Koss |
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Affiliation: | Department of Biochemistry, Dr. K. Thomas GmbH, D-7950 Biberach/Riss G.F.R. |
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Abstract: | A new fully automated high-performance liquid chromatograph is described which detects drugs from directly injected plasma (urine, saliva) without sample pretreatment. The apparatus consists of a programmable automatic sampling unit, which is connected via two alternating working pre-columns to an analytical column (“alternating pre-column sample enrichment”). The new device is able to operate with directly injected body fluids like an auto-analyzer and is especially useful for pharmacokinetic and clinical studies, where drug concentration have to be determined from plasma, urine or saliva. |
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