Isolation and identification of some guanidino compounds in the urine of patients with hyperargininaemia by liquid chromatography,thin-layer chromatography and gas chromatography-mass spectrometry |
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| Authors: | Bart Marescau Armand Lowenthal Eddy Esmans Yves Luyten Frank Alderweiereldt Heinz Georg Terheggen |
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| Affiliation: | Department of Neurochemistry, Born-Bunge Foundation, Universitaire Instelling Antwerpen, Universiteitsplein 1, B-2610 Wilrijk Belgium;University of Antwerp (RUCA), Laboratory for Organic Chemistry, Groenenborgerlaan 171, B-2020 Antwerpen Belgium;Children''s Hospital, Neuss G.F.R. |
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| Abstract: | Liquid column chromatographic studies of monosubstituted guanidino compounds, which are excreted in the urine of patients with hyperargininaemia are reported. The guanidino-positive peaks, with the highest excretion values, were isolated from urine and the isolated compounds were identified by thin-layer chromatography and gas chromatography—mass spectrometry. Guanidinoacetic acid, N-α-acetylarginine, argininic acid, γ-guanidinobutyric acid, arginine and α-keto-δ-guanidinovaleric acid were found to be excreted at high levels in the urine of patients with hyperargininaemia compared with controls. |
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