1. Laboratory of Electrothermophototherapy, Department of Physical Therapy, Federal University of Sao Carlos, SP, Brazil;2. Post‐Graduation Program in Biotechnology, Federal University of Sao Carlos, SP, Brazil;3. Optics Group, Physics Institute of Sao Carlos, University of S?o Paulo, Sao Carlos, SP, Brazil;4. Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom Street, Boston, MA 02114 USA;5. Laboratory of Radiation Dosimetry and Medical Physics, Institute of Physics, Sao Paulo University,, SP, Brazil;6. Federal University of Rio de Janeiro, RJ, Brazil;7. Department of Dermatology, Harvard Medical School, Boston, MA, USA;8. Graduate School Biomedical Engineering, Tohoku University, Japan;9. Harvard‐MIT Division of Health Science and Technology, Cambridge, MA, USA;10. Corresponding author: e‐mail:
Abstract:
Light‐emitting diode therapy (LEDT) applied over the leg, gluteus and lower‐back muscles of mice using a LED cluster (630 nm and 850 nm, 80 mW/cm2, 7.2 J/cm2) increased muscle performance (repetitive climbing of a ladder carrying a water‐filled tube attached to the tail), ATP and mitochondrial metabolism; oxidative stress and proliferative myocyte markers in mice subjected to acute and progressive strength training. Six bi‐daily training sessions LEDT‐After and LEDT‐Before‐After regimens more than doubled muscle performance and increased ATP more than tenfold. The effectiveness of LEDT on improving muscle performance and recovery suggest applicability for high performance sports and in training programs.
Positioning of the mice and light‐emitting diode therapy (LEDT) applied on mouse legs, gluteus and lower‐back muscles without contact.
