Antihyperlipidaemic,Antihypertrophic, and Reducing Effects of Zingerone on Experimentally Induced Myocardial Infarcted Rats

The present study aims to evaluate the antihyperlipidaemic, antihypertrophic, and reducing effects of zingerone on isoproterenol‐induced hyperlipidaemia and hypertrophy in rats. Rats were pretreated with zingerone (6 mg/kg body weight) daily for a period of 14 days and then induced myocardial infarction with isoproterenol (100 mg/kg body weight) on days 15 and 16. Isoproterenol increased serum creatine kinase and lactate dehydrogenase activities in the rats. Increased levels/concentrations of serum and heart cholesterol and triglycerides were observed in isoproterenol‐induced myocardial infarcted rats. Isoproterenol also altered serum lipoproteins and the activity of liver 3‐hydroxy‐3‐methyl glutaryl‐coenzyme‐A‐reductase in the rats. The in vitro study revealed a very convincing reducing power of zingerone. Pretreatment with zingerone prevented hyperlipidaemia and cardiac hypertrophy, by virtue of its antihyperlipidaemic, antihypertrophic, and reducing properties in isoproterenol‐induced myocardial infarcted rats.