2‐(2‐Nitrovinyl)furan Promotes Oxidation of Cellular Proteins,Lipids, and DNA of Male Rat Liver and Kidney |
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| Authors: | T O Ajiboye K A Alabi F A Ariyo A O Adeleye O B Ojewuyi A Balogun T O Sunmonu |
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| Institution: | 1. Antioxidants, Free Radicals, Functional Foods and Toxicology Research Laboratory, Department of Biological Sciences, Al‐Hikmah University, Ilorin, Nigeria;2. Industrial and Environmental Unit, Department of Chemical Sciences, Fountain University, Osogbo, Nigeria;3. Antioxidants, Free Radicals and Toxicology Research Laboratory, Biochemistry and Nutrition Unit, Department of Chemical Sciences, Fountain University, Osogbo, Nigeria;4. Plant Biochemistry and Phytomedicine Laboratory, Department of Biological Sciences, Al‐Hikmah University, Ilorin, Nigeria |
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| Abstract: | The effect of 2‐(2‐nitrovinyl)furan on the redox status of male rat liver and kidney was evaluated. Twenty male rats were randomized into four groups; group A received olive oil and groups B, C, and D rats received 12.5, 25, and 50 mg/kg bodyweight of 2‐(2‐nitrovinyl)furan intraperitoneally, daily at 24 h interval, respectively, for 14 days. 2‐(2‐Nitrovinyl)furan significantly reduced (P < 0.05) alkaline phosphatase, alanine, and aspartate aminotransferase activities in male rat liver and kidney with a corresponding increase in serum. The activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and levels of reduced glutathione/glutathione disulfide (GSSG) ratio in the liver and kidney of 2‐(2‐nitrovinyl)furan‐treated rats decreased significantly (P < 0.05). In contrast, GSSG, protein carbonyl, conjugated dienes, lipid hydroperoxides, malondialdehyde, and fragmented DNA (%) in 2‐(2‐nitrovinyl)furan‐treated rats increased significantly (P < 0.05). Overall, data from this study revealed that 2‐(2‐nitrovinyl)furan exhibited its toxic effect by suppressing or depleting the antioxidant systems. |
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| Keywords: | Nitrovinyl Furan Protein Oxidation DNA Fragmentation Lipid Peroxidation Redox Imbalance |
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