Mechanosensitivity of cell membranes |
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Authors: | Alexander G Petrov Peter N R Usherwood |
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Institution: | (1) Biomolecular Layers Department, Institute of Solid State Physics, Bulgarian Academy of Sciences, 72 Tzarigradsko chaussee, BG-1784 Sofia, Bulgaria;(2) Department of Life Science, Nottingham University, University Park, NG7 2RD Nottingham, UK |
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Abstract: | Physical and biophysical mechanisms of mechano-sensitivity of cell membranes are reviewed. The possible roles of the lipid matrix and of the cytoskeleton in membrane mechanoreception are discussed. Techniques for generation of static strains and dynamic curvatures of membrane patches are considered. A unified model for stress-activated and stress-inactivated ion channels under static strains is described. A review of work on stress-sensitive pores in lipid-peptide model membranes is presented. The possible role of flexoelectricity in mechano-electric transduction, e.g. in auditory receptors is discussed. Studies of flexoelectricity in model lipid membranes, lipid-peptide membranes and natural membranes containing ion channels are reviewed. Finally, possible applications in molecular electronics of mechanosensors employing some of the recognized principles of mechano-electric transduction in natural membranes are discussed.Abbreviations BLM
Layer lipid membrane
- SAC
stress-activated channel
- SIC
stress-inactivated channel
- MCYST
microcystin-LR
- DPhL
diphytanoyl lecithin
- CME
condenser microphone effect
Dedicated to Professor Alexander Derzhanski on the occasion of his 60th birthday
Correspondence to: A. G. Petrov |
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Keywords: | Mechanosensitivity Mechanotransduction Cell membrane complex Ion channels Modelling of stress-sensitivity Lipid matrix Cytoskeleton Mechano-electric phenomena Flexoelectricity Model membranes Mechanosensors |
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