The effect of cis-diamminedichloroplatinum (II) on the formation of DNA-Pt-DNA cross-links. |
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| Authors: | Z Walter M Spycha?a |
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| Affiliation: | Department of Molecular Genetics, University of Lód?, Poland. |
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| Abstract: | The effect of cis-diamminedichloroplatinum (II) (cis-DDP) on the formation of interstrand cross-links in DNA and in DNA and chromatin complex from leukocytes was studied. Following the use of cis-DDP the number of DNA-DNA interstrand cross-links was elevated with the increase of cis-DDP concentration and elongation of reaction time. It was also found that nucleic proteins reduce the quantity of the cis-DDP induced DNA-DNA interstrand cross-links in the DNA in nucleoprotein complex when compared with the links in the isolated DNA. |
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