| HL－60细胞诱导分化过程中TPK和PTPP活力的时空改变 |
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| 引用本文： | 白龙川,颜卉君,吴国利.HL－60细胞诱导分化过程中TPK和PTPP活力的时空改变[J].中国生物化学与分子生物学报,1995,11(3):333-337. |
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| 作者姓名： | 白龙川 颜卉君 吴国利 |
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| 作者单位： | 北京师范大学分子生物学及生物化学研究室 |
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| 摘 要： | 对ＲＡ、ＨＨＴ和ＷＰ_（８５２）诱导ＨＬ－６０细胞分化过程中胞浆和膜溶脱部分中的ＴＰＫ和ＰＴＰＰ活力变化进行了研究．结果表明，在诱导早期，ＴＰＫ的活力就有明显的波动变化；随着诱导时间的延长，胞浆部分ＴＰＫ活力下降，膜溶脱部分的ＴＰＫ活力则升高．诱导后，胞浆部分和膜溶脱部分的ＰＴＰＰ活力均明显升高。与ＴＰＫ活力变化相比较，ＰＴＰＰ变化幅度比ＴＰＫ的大。
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| 关 键 词： | 人早幼粒白血病细胞（HL－60） 酪氨酸蛋白激酶（TPK） 磷酸酪氨酸蛋白磷酸酶（PTPP） 维甲酸（RA） 高三尖杉酯碱（HHT） 峨术醇衍生物（WB_（852）） |
| 收稿时间： | 1995-06-20 |
Temporal & Spatial Alternations of TPK and PTPP Activities During the Induced Differentiation of Human Promyelotic Leukemia Cells (HL-60) |
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| Bai Long-Chuan,Yan Hui-Jun,Wu Guo-Li.Temporal & Spatial Alternations of TPK and PTPP Activities During the Induced Differentiation of Human Promyelotic Leukemia Cells (HL-60)[J].Chinese Journal of Biochemistry and Molecular Biology,1995,11(3):333-337. |
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| Authors: | Bai Long-Chuan Yan Hui-Jun Wu Guo-Li |
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| Institution: | (Laboratory of Molecular Biology and Biochemistry,Beijing Normal University,Beijing 100875 |
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| Abstract: | Alternations of TPK and PTPP activities in cytosol and membrane fractions were studied during the differentiation of HL-60 cells induced by RA. HHT and WB_(852). It was found that the activity of TPK showed a distinct fluctuation in the early stage of differentiation and with the elongation of differentiation,it declined in cytosol fraction and increased in membrane fraction. It was also found that the activity of PTPP increased distinctly both in cytosol and memerane fractions. The range of increase was greater than the range in change of TPK activity. |
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