Stimulation of gluconeogenesis by somatostatin in rat kidney cortex slices. |
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| Authors: | J.A. Lupiáñez K.N. Dileepan S.R. Wagle |
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| Affiliation: | Department of Pharmacology Indiana University School of Medicine Indianapolis, Indiana 46223 USA |
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| Abstract: | The effect of somatostatin on gluconeogenesis was studied in kidney cortex slices. Addition of somatostatin (2 μg) stimulated gluconeogenesis from lactate, pyruvate and glutamine by 42%, 50% and 68% respectively. Stimulation of glucose synthesis from lactate by somatostatin was found to be linear with time and dose dependent between 0.1 and 20 μg. Somatostatin-stimulated gluconeogenesis was inhibited by phentolamine (10 μM) but not by propranolol (10 μM) suggesting that somatostatin action is mediated by α-adrenergic stimuli. |
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