Succinimide hydroxamic acids as potent inhibitors of histone deacetylase (HDAC) |
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| Authors: | Curtin Michael L Garland Robert B Heyman H Robin Frey Robin R Michaelides Michael R Li Junling Pease Lori J Glaser Keith B Marcotte Patrick A Davidsen Steven K |
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| Affiliation: | Cancer Research Area, Abbott Laboratories, Dept. 47J, Bldg. AP10, 100 Abbott Park Road, Abbott Park, IL 60064, USA. mike.curtin@abbott.com |
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| Abstract: | A series of succinimide hydroxamic acids was prepared and evaluated in vitro for HDAC inhibition and tumor cell antiproliferation. While the original macrocyclic analogue 6 was quite potent in both assays, several appropriately substituted non-macrocyclic succinimides, such as 23, were equipotent. |
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