首页 | 本学科首页   官方微博 | 高级检索  
   检索      


An update on antigenic variation in African trypanosomes.
Authors:L Vanhamme  E Pays  R McCulloch  J D Barry
Institution:Laboratory of Molecular Parasitology, IBMM, Free University of Brussels, Rue des Professeurs Jeener et Brachet 12, B-6041, Gosselies, Belgium. Ivanham@dbm.ulb.ac.be
Abstract:African trypanosomes can spend a long time in the blood of their mammalian host, where they are exposed to the immune system and are thought to take advantage of it to modulate their own numbers. Their major immunogenic protein is the variant surface glycoprotein (VSG), the gene for which must be in one of the 20–40 specialized telomeric expression sites in order to be transcribed. Trypanosomes escape antibody-mediated destruction through periodic changes of the expressed VSG gene from a repertoire of ∼1000. How do trypanosomes exclusively express only one VSG and how do they switch between them?
Keywords:
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号