Localization of a determinant mediating partial macrolide resistance in Staphylococcus aureus |
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Authors: | M Matsuoka K Endou Y Nakajima |
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Institution: | Division of Microbiology, Hokkaido Institute of Pharmaceutical Sciences. |
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Abstract: | Four out of more than 8,200 Staphylococcus aureus strains isolated in Japan between 1961 and 1980 were constitutively resistant to a variety of macrolide antibiotics except tylosin and rokitamycin, but susceptible to lincosamide and streptogramin type B antibiotics (PM). The data obtained by agarose gel electrophoresis, CsCl-ethidium bromide density gradient analysis, diagnosis with ATP-dependent deoxyribonuclease, and a test transducing into a rec- mutant with phage 80L2 propagated on PM-resistant S. aureus all suggested that the determinant for the PM-resistance is located in chromosome. |
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