Characterization of human-specific DNA sequences obtained by genome subtraction |
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Authors: | Y Watanabe S Ueda |
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Institution: | (1) Department of Anthropology, Graduate School of Science, University of Tokyo, Tokyo, Japan |
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Abstract: | Recent studies on molecular evolution using nucleotide sequence data to clarify phylogenetic relationships among humans and
the African great apes, have revealed that humans are more closely related to chimpanzees than to gorillas. However, the genetic
basis of human uniqueness remains unclear. This is because phylogenetic studies have merely evaluated the degree of similarity
by calculating the accumulation of nucleotide substitutions that have occurred in neutral DNA regions commonly present in
all the species examined. In contrast, the genome subtraction method recently developed by us has revealed dissimilarity even
among the genomes of the most closely related species. Here we describe the characteristics of the DNA sequences obtained
by genome subtraction between humans and chimpanzees. |
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Keywords: | human-specific DNAs specres uniqueness genome subtraction |
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