| 层粘连蛋白与疾病相关性的研究进展 |
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| 引用本文： | 赵晓芳,孟程程,李招发.层粘连蛋白与疾病相关性的研究进展[J].生物技术通讯,2010,21(1):116-120. |
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| 作者姓名： | 赵晓芳 孟程程 李招发 |
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| 作者单位： | 华侨大学,分子药物学研究所,福建,泉州,362021;分子药物教育部工程研究中心,福建,泉州,362021 |
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| 基金项目： | 福建省重点项目，华侨大学科研基金 |
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| 摘 要： | 层粘连蛋白(lanminin,LN)是由3条多肽链组成的异源三聚体,是基膜的主要成分,存在于多种组织中,它可识别细胞表面受体从而使基膜与细胞紧密结合。LN参与基膜的构建及细胞的黏附、生长、增殖、迁移和分化,是机体正常生长发育所必需的。LN的不正常表达常常与肿瘤以及皮肤、神经-骨骼肌、肝、肾等组织疾病的发生发展密切相关。通过深入探讨LN与疾病及肿瘤发生、发展的关系,有望为相关疾病及肿瘤的治疗开拓新的思路。
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| 关 键 词： | 基膜 层粘连蛋白 疾病 肿瘤 |
Progress of Relationship Between Laminins and Their Related Diseases |
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| ZHAO Xiao-Fang,MENG Cheng-Cheng,LI Zhao-Fa.Progress of Relationship Between Laminins and Their Related Diseases[J].Letters in Biotechnology,2010,21(1):116-120. |
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| Authors: | ZHAO Xiao-Fang MENG Cheng-Cheng LI Zhao-Fa |
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| Institution: | ZHAO Xiao-Fang1,2,MENG Cheng-Cheng1,LI Zhao-Fa1,2 1.Institue of Molecular Medicine,Huaqiao University,Quanzhou 362021,2.Molecular Medicine Engineering Research Center of Ministry of Education,China |
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| Abstract: | The members of the laminin(LN)family composed of three different polypeptide chains are major basement membrane proteins.They are present in almost all organs.The LN bind to cell surface receptors and thereby tightly connect the basement membrane to the adjacent cell layer.LN is involved in the construction of basement membrane and cell adhesion,growth,proliferation,migration and differentiation,so it is essential to normal growth and development.Abnormal expression of LN is closely related to the developme... |
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| Keywords: | basement membrane laminin disease cancer |
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