CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis |
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| Authors: | Marino A P M P Silva A A Santos P V A Pinto L M O Gazinelli R T Teixeira M M Lannes-Vieira J |
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| Affiliation: | Laboratório de Autoimunidade e Imuno-regula??o, Departamento de Imunologia, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, 21040-900, Brasil. |
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| Abstract: | The comprehension of the pathogenesis of Trypanosoma cruzi-elicited myocarditis is crucial to delineate new therapeutic strategies aiming to ameliorate the inflammation that leads to heart dysfunction, without hampering parasite control. The augmented expression of CCL5/RANTES and CCL3/MIP-1alpha, and their receptor CCR5, in the heart of T. cruzi-infected mice suggests a role for CC-chemokines and their receptors in the pathogenesis of T. cruzi-elicited myocarditis. Herein, we discuss our recent results using a CC-chemokine receptor inhibitor (Met-RANTES), showing the participation of CC-chemokines in T. cruzi infection and unraveling CC-chemokine receptors as an attractive therapeutic target for further evaluation in Chagas disease. |
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