Lantibiotic nisin Z fermentative production by Lactococcus lactis IO-1: relationship between production of the lantibiotic and lactate and cell growth |
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| Authors: | H Matsusaki N Endo K Sonomoto A Ishizaki |
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| Institution: | (1) Laboratory of Microbial Technology, Department of Food Science and Technology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812, Japan. Fax: (092) 632 1962, JP |
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| Abstract: | The influence of several parameters on the fermentative production of nisin Z by Lactococcus lactis IO-1 was studied. Considerable attention has been focused on the relationship between the primary metabolite production of
bacteriocin and lactate and cell growth, which has so far not been clarified in detail. Production of nisin Z was optimal
at 30°C and in the pH range 5.0–5.5. The addition of Ca2+ to the medium showed a stimulating effect on the production of nisin Z. A maximum activity of 3150 IU/ml was obtained during
pH-controlled batch fermentation in the medium supplemented with 0.1 M CaCl2. It was about three times higher than that obtained under the optimal conditions for cell growth and lactic acid production.
Received: 12 July 1995/Received revision: 11 September 1995/Accepted: 4 October 1995 |
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