Developmental changes in rat liver alcohol dehydrogenase |
| |
Authors: | Pushkaraj J Lad William J Shoemaker Hyam L Leffert |
| |
Institution: | 1. Department of Medicine, Division of Pharmacology, M-013 H, University of California, San Diego, La Jolla, California 92093, USA;2. Alcohol Research Center, The Salk Institute for Biological Studies, P.O. Box 85800 San Diego, California 92108 USA |
| |
Abstract: | Hepatic alcohol dehydrogenase activity and mass content change coordinately during development in male rats. Enzyme activity and mass content increase continuously after birth to 100 and 80% of maximal values within 6 weeks (2.6 ± 0.4 μmole/min/g liver and 92 ± 20 μg/g liver), respectively. When expressed per milligram of soluble proteins, both parameters peak at 3 weeks (0.052 ± 0.002 μmole/min/mg protein and 2.0 ± 0.4 μg/mg protein) and then decrease gradually to plateau levels. These decreases probably arise from a “surge” in soluble liver protein levels that occurs after weaning. Similar developmental patterns also occur in female rats. These findings are the first quantitative measurements of this enzyme in developing animals. |
| |
Keywords: | Please address correspondence to H L Leffert |
本文献已被 ScienceDirect 等数据库收录! |
|