Hydrophobic cluster analysis reveals duplication in the external structure of human alpha-interferon receptor and homology with gamma-interferon receptor external domain |
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Authors: | C Gaboriaud G Uzé G Lutfalla K Mogensen |
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Affiliation: | Laboratoire de Minéralogie-Cristallographie, CNRS U A09, Université P6, France. |
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Abstract: | Evidence is presented, based on sequence comparison according to Hydrophobic Cluster Analysis, of a structural and evolutionary relationship between the human alpha/beta-interferon receptor and the human and mouse gamma-interferon receptor. These results predict that the human alpha/beta-interferon receptor extracellular part is organised in two homologous subdomains connected by a proline linker. They also predict that both subdomains present some homologies to the external domain of mouse and human gamma interferon receptor. |
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