Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase |
| |
| Authors: | Shankaran K Donnelly Karla L Shah Shrenik K Guthikonda Ravindra N MacCoss Malcolm Humes John L Pacholok Stephen G Grant Stephan K Kelly T M Wong K K |
| |
| Affiliation: | Department of Medicinal Chemistry, Merck Research Laboratory, PO Box 2000, Rahway, NJ 07065, USA. kothandaraman_shankaran@merck.com |
| |
| Abstract: | Syntheses and evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase (NOS) are discussed. An extensive SAR was established for pyrrolidin-2-imines class of compounds. The amidines came out as the most potent inhibitors in addition to displaying selectivity. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
