| 手性Schiff－Base在手性PTC条件下的双不对称诱导烷基化 |
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| 引用本文： | 郑志兵,陈子康,俞凌. 手性Schiff－Base在手性PTC条件下的双不对称诱导烷基化[J]. 氨基酸和生物资源, 1994, 0(2) |
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| 作者姓名： | 郑志兵 陈子康 俞凌 |
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| 作者单位： | 军事医学科学院毒物药物研究所，北京师范大学化学系 |
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| 摘 要： | 本文报道了以苯甲醛甘氨酸酯〔乙酯，（—）—簿荷醇酯〕西佛碱作为反应底物，烯丙基溴，溴苄，对硝基溴作为烷基化试剂，在以（—）—Ｎ—基氯化辛可宁丁，（＋）－Ｎ基氯化辛可宁作为催化剂的固液相转移条件下的双不对称诱导烷基化反应，进而水解得到α—光学活性氨基酸。光学产率为２．５７—２２．４％，实验中观察到了双不对称诱导效应。
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^Double Asymmetric induction Alkylation of Chiral Schiff-Bases under chiral PTC Canditions |
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| Affiliation: | ,Zheng Zhingbing(Institute of pharmacology and Toxicology acdemy of military Medical Sciences Beijing 100850)Chen Zikang, Yu Lingchong(department of chemistry,Beijing normal university,Beijing 100875) |
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| Abstract: | Using the choral stiff-Base synthesized by the reaction of benzaldehyde and glycine ester ethyl,(-) menthyl as substrate and allyl bromide, benzyl bromide, 4-nitrobenzyl bromide as Alkylating regents, Double asymmetric induction alkylation under solid-liquid phase transfer condition Catalyzed by (-)-N-benzylcinchonidinium chlorlde and (+)-N-benzylcinchonine chloride have been reported in this paper. A single and double asymmitric induction effect has been observed in the alkylating reaction, the ee% of optical active amino acid ranges from 25% to 22.9%. |
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