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Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells |
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| Authors: | Nakao Yoichi Narazaki Genta Hoshino Takuhiro Maeda Satoko Yoshida Minoru Maejima Hiroshi Yamashita Jun K |
| Affiliation: | aDepartment of Chemistry and Biochemistry, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan bInstitute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan cChemical Genetics Laboratory, RIKEN, Saitama 351-0198, Japan |
| Abstract: | Evaluation of antiangiogenic activity of marine sponge derived azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells was carried out. Azumamide E (5) strongly inhibited in vitro angiogenesis from iPS cells at 1.9 μM while azumamide A (1) showed only weak inhibition at 19 μM. These results were well correlated with HDAC inhibitory activity of these compounds, revealing the prospect of azumamides as the probe molecules useful for stem cell chemical biology. |
| Keywords: | iPS cells Histone deacetylase Angiogenesis Chemical biology |
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