INDUCTION OF HEPATOCYTE GROWTH FACTOR IN THE LIVER, KIDNEY AND LUNG FOLLOWING TOTAL BODY IRRADIATION IN RAT |
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| Authors: | Hideya Yamazaki Khunio Matsumoto Takehiro Inoue Takayuki Nose Shigeyuki Murayama Teruki Teshima Shuji Ozeki Masahiko Koizumi Toshikazu Nakamura Toshihiko Inoue |
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| Institution: | aDepartment of Radiation Oncology, Biomedical Research Center, Osaka University Medical School, Japan;bDivision of Biochemistry, Biomedical Research Center, Osaka University Medical School, Japan;cDepartment of Radiology, Osaka University Medical School, Japan |
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| Abstract: | Hepatocyte factor (HGF) has been shown to have a pleiotropic function to act as a potent organotropic factor in the regeneration of injury in various organs, including the liver, kidney and lung. To examine the involvement of HGF in radiation injury, the authors analysed the changes in HGF mRNA and HGF protein levels in the rat organs (liver, lung, kidney) and plasma following 6 Gy of total body irradiation. Expression of HGF mRNA in the liver and kidney increased 6–48 h after total body irradiation and returned to previous values 1 week later. HGF protein levels in lung and liver showed 1.3-2 fold elevations 1–2 weeks after irradiation (P< 0.05). HGF levels in plasma stayed at undetectable levels up to 1 month after total body irradiation. The labelling index determined 2 weeks and 1 month after total body irradiation indicated no enhancement of regeneration. Thus, total body irradiation induced transient HGF elevation in these organs without enhancement of regeneration |
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| Keywords: | hepatocyte growth factor total body irradiation rat |
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