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Oncogenic translation directs spliceosome dynamics revealing an integral role for SF3A3 in breast cancer
Authors:Maciej Cieśla  Phuong Cao Thi Ngoc  Eugenia Cordero  Álvaro Sejas Martinez  Mikkel Morsing  Sowndarya Muthukumar  Giulia Beneventi  Magdalena Madej  Roberto Munita  Terese Jönsson  Kristina Lövgren  Anna Ebbesson  Björn Nodin  Ingrid Hedenfalk  Karin Jirström  Johan Vallon-Christersson  Gabriella Honeth  Johan Staaf  Cristian Bellodi
Affiliation:1. Division of Molecular Hematology, Department of Laboratory Medicine, Lund Stem Cell Center, Faculty of Medicine, Lund University, 22184 Lund, Sweden;2. Division of Translational Cancer Research, Department of Laboratory Medicine, Faculty of Medicine, Lund University, 22363 Lund, Sweden;3. Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden;4. Faculty of Science and Engineering, University of Groningen, Groningen, the Netherlands;5. Department of Hematology, Oncology and Radiation Physics, Skåne University Hospital, Lund, Sweden
Abstract:
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  • Keywords:alternative splicing  MYC  SF3A3  translation control  eIF3D  mitochondrial dynamics  DRP1  triple-negative breast cancer  cancer stem cells  cancer plasticity
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