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R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis
Authors:Ying Qing  Lei Dong  Lei Gao  Chenying Li  Yangchan Li  Li Han  Emily Prince  Brandon Tan  Xiaolan Deng  Collin Wetzel  Chao Shen  Min Gao  Zhenhua Chen  Wei Li  Bin Zhang  Daniel Braas  Johanna ten Hoeve  Gerardo Javier Sanchez  Jianjun Chen
Affiliation:1. Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA;2. Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA;3. Department of Pathology and Genomic Medicine, Houston Methodist, Houston, TX 77030, USA;4. Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA;5. Department of Hematologic Malignancies Translational Science, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA;6. UCLA Metabolomics Center, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA;7. Department of Diabetes Complications and Metabolism, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA;8. Molecular and Cellular Endocrinology, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA;9. Key Laboratory of Hematopoietic Malignancies, The First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang 31003, China;10. Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China;11. School of Pharmacy, China Medical University, Shenyang, Liaoning 110001, China;12. School of Pharmaceutical Science and Technology, Tianjin Key Laboratory for Modern Drug Delivery and High Efficiency, and Collaborative Innovation Center of Chemical Science and Engineer (Tianjin), Tianjin University, Tianjin 300072, China;13. City of Hope Comprehensive Cancer Center, City of Hope, Duarte, CA 91010, USA;14. Department of Internal Medicine (Hematology) and Center of Molecular and Cellular Oncology, Yale Cancer Center, Yale School of Medicine, New Haven, CT 06511, USA;15. Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA 91010, USA
Abstract:
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  • Keywords:R-2HG  FTO  leukemia  cancer metabolism  glycolysis  PFKP  LDHB  YTHDF2  RNA stability
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