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XRCC1 prevents toxic PARP1 trapping during DNA base excision repair
Authors:Annie A. Demin  Kouji Hirota  Masataka Tsuda  Marek Adamowicz  Richard Hailstone  Jan Brazina  William Gittens  Ilona Kalasova  Zhengping Shao  Shan Zha  Hiroyuki Sasanuma  Hana Hanzlikova  Shunichi Takeda  Keith W. Caldecott
Affiliation:1. Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9RQ, UK;2. Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Yoshidakonoe, Sakyo-ku, Kyoto 606-8501, Japan;3. Department of Chemistry, Tokyo Metropolitan University, Minami-Osawa, Hachioji-shi, Tokyo 192-0397, Japan;4. Program of Mathematical and Life Sciences, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima 739-8526, Japan;5. Department of Genome Dynamics, Institute of Molecular Genetics of the Czech Academy of Sciences, 142 20 Prague 4, Czech Republic;6. Institute for Cancer Genetics, Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York City, NY 10032, USA;7. Division of Pediatric Oncology, Hematology and Stem Cell Transplantation, Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Abstract:
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  • Keywords:base excision repair  single-strand breaks  PARP inhibitors  PARP trapping  XRCC1 protein complexes  PARP1
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