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Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance

Authors:	Ruben Schep Eva K Brinkman Christ Leemans Xabier Vergara Robin H van der Weide Ben Morris Tom van Schaik Stefano G Manzo Daniel Peric-Hupkes Jeroen van den Berg Roderick L Beijersbergen René H Medema Bas van Steensel

Institution:	1. Oncode Institute, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands;2. Division of Gene Regulation, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands;3. Division of Cell Biology, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands;4. Division of Molecular Carcinogenesis, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands;5. Robotics Screening Center, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands;6. Department of Cell Biology, Erasmus University Medical Centre, 3015 CN, Rotterdam, the Netherlands

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Keywords:	CRISPR Chromatin DNA repair double strand break MMEJ NHEJ SSTR reporter assay nuclear lamina heterochromatin
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