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Factor XII deficiency in asymptomatic Saudi population: A retrospective cohort study |
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| Authors: | Fatmah S Alqahtany Farjah H Algahtani Mashael M Alshebly Thamer S Albegamy Essam S Alghamdi Mohammed A Alnakhli Fatimah M Madkhaly Abdullah A Alharbi Nawaf A Alqahtani |
| Institution: | 1. Department of Pathology, Hematopathology Unit, College of Medicine, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia;2. Department of Medicine, Division of Oncology/Hematology, College of Medicine, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia;3. Department of Obstetrics and Gynecology, College of Medicine, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia;4. Heamatopathology & Blood Transfusion Consultant, Ministry of Health, Riyadh, Saudi Arabia;5. College of Medicine, King Saud Bin Abdul Aziz University for Health Sciences, Riyadh, Saudi Arabia |
| Abstract: | Factor XII (FXII) deficiency is a rare genetic blood disorder. It can lead to a higher risk of developing deep vein thrombosis or acquired thrombotic disorders than the general population. This retrospective study evaluated patients who opted for surgery and were found to have abnormal clotting profiles and clotting factors on preoperative routine blood. Patients were included regardless of whether they were symptomatic or asymptomatic. The cohort comprised 115 patients with a mean FXII level of 128.04 ± 36.93%. Two (1.79%) patients, both of whom were women, had FXII levels <60%. The mean FXII level was 58 ± 1.41 (range, 57–59%) in this group. The present study shows the prevalence of FXII in the asymptomatic Saudi population. The results provide the normal range for FXII. The findings of our study provide the basis for diagnosing F XII deficiency in the asymptomatic Saudi population. |
| Keywords: | Coagulation factors Factor XII deficiency Hageman factor Thrombosis Recurrent miscarriage |
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