Manganese-doped cerium oxide nanocomposite as a therapeutic agent for MCF-7 adenocarcinoma cell line |
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| Authors: | M Atif Seemab Iqbal M Fakhar-e-Alam Qaisar Mansoor KS Alimgeer Amanullah Fatehmulla Atif Hanif Nafeesah Yaqub WA Farooq Shafiq Ahmad Hijaz Ahmad Yu-ming Chu |
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| Institution: | 1. Department of Physics and Astronomy, College of Science, King Saud University, Riyadh 11451, Saudi Arabia;2. Department of Physics, GC University, Faisalabad 38000 Pakistan;3. Institute of Biomedical and Genetic Engineering, Islamabad, Pakistan;4. Department of Electrical and Computer Engineering, COMSATS University, Islamabad, Islamabad campus, Pakistan;5. Botany and Microbiology Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia;6. Industrial Engineering Department, College of Engineering, King Saud University, P.O. Box 800, Riyadh 11421, Saudi Arabia;7. Department of Basic Sciences, University of Engineering and Technology, Peshawar 25000, Pakistan;8. Section of Mathematics, International Telematic University Uninettuno, Corso Vittorio Emanuele II, 39, 00186 Roma, Italy;9. Department of Mathematics, Huzhou University, Huzhou 313000, China;10. Hunan Provincial Key Laboratory of Mathematical Modeling and Analysis in Engineering, Changasha, University of Science & Technology, Changsha 410114, China |
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| Abstract: | The preparation of a manganese-doped cerium oxide (Mn:CeO2) nanocomposite via hydrothermal route is described. Cubic fluorite structure of single phase was exhibited by studying structural analysis through x-ray diffraction (XRD) technique and morphological analysis was conducted by scanning electron microscope. Surface analytic technique of energy dispersive x-ray spectroscopy (EDX) was conducted to analyze the relative amount of any impurity and doping. Structural changes due to manganese doping such as increment in production of vacancies of oxygen within crystal of cerium oxide, and reduction in size of crystallite and constant of lattice was observed in our research study. Moreover, the Mn:CeO2 nanocomposite demonstrates differential cytotoxicity against MCF-7 adenocarcinoma cell line, which renders it a promising candidate for targeted cancer therapy. The anti-tumorous activity of the cerium oxide nanocomposite was significantly enhanced with doping of manganese, which is directly linked with the generation of highly reactive oxygen facets. The experimental results are supported by a mathematical model that confirms a confidence level of 95%. This research has paved the way for many utilities in therapeutics and magnetic resonance imaging diagnostics through new observations, and hence verified their math model. |
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| Keywords: | XRD SEM MCF-7 adenocarcinoma cell line Cytotoxicity Mathematical modeling Cancer therapy |
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