Identification of defective early immune responses to Burkholderia pseudomallei infection in a diet-induced murine model of type 2 diabetes |
| |
| Authors: | Jodie L. Morris Brenda L. Govan Catherine M. Rush Natkunam Ketheesan |
| |
| Affiliation: | 1. College of Medicine and Dentistry, James Cook University, Queensland, 4811, Australia;2. College of Public Health, Medical and Veterinary Sciences, James Cook University, Queensland, 4811, Australia;3. Science & Technology, University of New England, New South Wales, 2351, Australia;1. State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention, Beijing 102206, China;2. Beijing Engineering Research Center of Protein and Antibody, Sinocelltech Ltd., Beijing 100176, China;1. Bio-Manguinhos, Oswaldo Cruz Foundation, Brazilian Ministry of Health, Rio de Janeiro, RJ, Brazil;2. Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Brazilian Ministry of Health, Rio de Janeiro, RJ, Brazil;3. National Institute of Science and Technology of Innovation on Diseases of Neglected Populations, Center for Technological Development in Health, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil;4. São Paulo State University, Institute of Biosciences, Coastal Campus of São Vicente, São Paulo, SP, Brazil |
| |
| Abstract: | Co-occurrence of bacterial infections with type 2 diabetes (T2D) is a global problem. Melioidosis caused by Burkholderia pseudomallei is 10 times more likely to occur in patients with T2D, than in normoglycemic individuals. Using an experimental model of T2D, we observed that greater susceptibility in T2D was due to differences in proportions of infiltrating leucocytes and reduced levels of MCP-1, IFN-γ and IL-12 at sites of infection within 24 h post-infection. However, by 72 h the levels of inflammatory cytokines and bacteria were markedly higher in visceral tissue and blood in T2D mice. In T2D, dysregulated early immune responses are responsible for the greater predisposition to B. pseudomallei infection. |
| |
| Keywords: | Type 2 diabetes Melioidosis Host–pathogen interactions Mouse model of diabetes |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
