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Transient plasma cell dyscrasia in COVID-19 patients linked to IL-6 triggering |
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| Authors: | A. Farina R. Labriola C. Ialongo M. Suppa V. Viggiani M. Lucarelli E. Anastasi A. Angeloni |
| Affiliation: | 1. Department of Experimental Medicine, University of Rome “La Sapienza”, 00161, Roma, Lazio, Italy;2. Department of Emergency Medicine, University of Rome “La Sapienza”, 00161, Roma, Lazio, Italy;3. Department of Molecular Medicine, University of Rome “La Sapienza”, 00161, Roma, Lazio, Italy |
| Abstract: | An unusual clonal gammopathy was reported in COVID-19 patient but whether this anomaly is related or not to the disease has not yet been clarified. To this aim, we selected a cohort of 35 COVID-19 patients swab positive and investigated serological levels of IL-6, immune response to major viral antigens and electrophoretic profile. Elevated levels of IL-6 were accompanied by a significative humoral response to viral Spike protein, revealing an altered electrophoretic profile in the gamma region. We can conclude that elevated levels of IL-6 triggers humoral response inducing a transient plasma cell dyscrasia in severe COVID-19 patients. |
| Keywords: | Sars-CoV-2 Covid-19 Cytokine storm IL-6 Immunoglobulins Plasma cell dyscrasia |
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