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Global analysis of protein-RNA interactions in SARS-CoV-2-infected cells reveals key regulators of infection
Authors:Wael Kamel  Marko Noerenberg  Berati Cerikan  Honglin Chen  Aino I. Järvelin  Mohamed Kammoun  Jeffrey Y. Lee  Ni Shuai  Manuel Garcia-Moreno  Anna Andrejeva  Michael J. Deery  Natasha Johnson  Christopher J. Neufeldt  Mirko Cortese  Michael L. Knight  Kathryn S. Lilley  Javier Martinez  Ilan Davis  Alfredo Castello
Affiliation:1. MRC-University of Glasgow Centre for Virus Research, G61 1QH Glasgow, Scotland, UK;2. Department of Biochemistry, University of Oxford, South Parks Road, OX1 3QU Oxford, UK;3. Department of Infectious Diseases, Molecular Virology, Heidelberg University, 69120 Heidelberg, Germany;4. German Center for Infection Research, Heidelberg Partner Site, 69120 Heidelberg, Germany;5. German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany;6. Sir William Dunn School of Pathology, University of Oxford, South Parks Road, OX1 3RE Oxford, UK;7. Department of Biochemistry, University of Cambridge, CB2 1GA Cambridge, UK;8. Center of Medical Biochemistry, Max Perutz Labs, Medical University of Vienna, Vienna, Austria;9. Department of Chemistry, University of Oxford, Mansfield Road, OX1 3TA Oxford, UK;10. Division Virus-Associated Carcinogenesis, Germany Cancer Research Center (DKFZ), 69120 Heidelberg, Germany;11. The Rosalind Franklin Institute, OX11 0FA Oxfordshire, UK
Abstract:
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  • Keywords:RNA  SARS-CoV-2  COVID-19  RNA-binding protein  RNA interactome  host-virus interactions  ribonucleoprotein  tRNA ligase  antivirals  viral replication  HSP90
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