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mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
Authors:Elodie Villa  Umakant Sahu  Brendan P. O’Hara  Eunus S. Ali  Kathryn A. Helmin  John M. Asara  Peng Gao  Benjamin D. Singer  Issam Ben-Sahra
Affiliation:1. Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA;2. Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA;3. Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA;4. Simpson Querrey Center for Epigenetics, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, USA;5. Mass Spectrometry Core, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA;6. Metabolomics Core Facility, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA
Abstract:
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  • Keywords:mTOR  mTORC1  MAT2A  Methionine cycle  S-adenosylmethionine  WTAP  RNA metabolism  Cell growth  Protein Synthesis
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