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Mitochondrial NAD+ Controls Nuclear ARTD1-Induced ADP-Ribosylation
Authors:Ann-Katrin Hopp  Federico Teloni  Lavinia Bisceglie  Corentin Gondrand  Fabio Raith  Kathrin Nowak  Lukas Muskalla  Anna Howald  Patrick G.A. Pedrioli  Kai Johnsson  Matthias Altmeyer  Deena M. Leslie Pedrioli  Michael O. Hottiger
Affiliation:1. Department of Molecular Mechanisms of Disease (DMMD), University of Zurich, 8057 Zurich, Switzerland;2. Life Science Zurich Graduate School, Molecular Life Science Ph.D. Program, University of Zurich, 8057 Zurich, Switzerland;3. Department of Chemical Biology, Max Planck Institute for Medical Research, 69120 Heidelberg, Germany;4. Faculty of Chemistry and Earth Sciences, University of Heidelberg, 69120 Heidelberg, Germany;5. Life Science Zurich Graduate School, Cancer Biology Ph.D. Program, University of Zurich, 8057 Zurich;6. Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, 8093 Zurich, Switzerland;7. PHRT-CPAC, ETH Zurich, 8093 Zurich, Switzerland
Abstract:
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  • Keywords:mitochondria  ADP-ribosylation  PARP-inhibitor  ARTD1  PARP1  NAD  mitochondrial ADP-ribosylation  mito-nuclear crosstalk  PARP inhibitors  DNA damage
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