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Mitochondrial NAD+ Controls Nuclear ARTD1-Induced ADP-Ribosylation
Authors:Ann-Katrin Hopp  Federico Teloni  Lavinia Bisceglie  Corentin Gondrand  Fabio Raith  Kathrin Nowak  Lukas Muskalla  Anna Howald  Patrick GA Pedrioli  Kai Johnsson  Matthias Altmeyer  Deena M Leslie Pedrioli  Michael O Hottiger
Institution:1. Department of Molecular Mechanisms of Disease (DMMD), University of Zurich, 8057 Zurich, Switzerland;2. Life Science Zurich Graduate School, Molecular Life Science Ph.D. Program, University of Zurich, 8057 Zurich, Switzerland;3. Department of Chemical Biology, Max Planck Institute for Medical Research, 69120 Heidelberg, Germany;4. Faculty of Chemistry and Earth Sciences, University of Heidelberg, 69120 Heidelberg, Germany;5. Life Science Zurich Graduate School, Cancer Biology Ph.D. Program, University of Zurich, 8057 Zurich;6. Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, 8093 Zurich, Switzerland;7. PHRT-CPAC, ETH Zurich, 8093 Zurich, Switzerland
Abstract:
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  • Keywords:mitochondria  ADP-ribosylation  PARP-inhibitor  ARTD1  PARP1  NAD  mitochondrial ADP-ribosylation  mito-nuclear crosstalk  PARP inhibitors  DNA damage
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