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Gating movements and ion permeation in HCN4 pacemaker channels
Authors:Andrea Saponaro  Daniel Bauer  M Hunter Giese  Paolo Swuec  Alessandro Porro  Federica Gasparri  Atiyeh Sadat Sharifzadeh  Antonio Chaves-Sanjuan  Laura Alberio  Giacomo Parisi  Gabriele Cerutti  Oliver B Clarke  Kay Hamacher  Henry M Colecraft  Filippo Mancia  Wayne A Hendrickson  Steven A Siegelbaum  Dario DiFrancesco  Anna Moroni
Institution:1. Department of Biosciences, University of Milan, Milan, Italy;2. Department of Biology, TU-Darmstadt, Darmstadt, Germany;3. Department of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA;4. Pediatric Research Center “Romeo ed Enrica Invernizzi,” University of Milan, Milan, Italy;5. Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK;6. Center for Life Nano Science, Istituto Italiano di Tecnologia, Rome, Italy;7. Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy;8. Department of Anesthesiology, Columbia University, New York, NY, USA;9. Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA;10. Department of Neuroscience, Zuckerman Institute, Columbia University, New York, NY, USA;11. Institute of Biophysics-Milano, Consiglio Nazionale delle Ricerche, Rome, Italy
Abstract:
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  • Keywords:HCN4  pore  gating  selectivity  permeation  cAMP  metal ion  cryo-EM  molecular dynamics  pacemaker
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