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Chemical-genetic interrogation of RNA polymerase mutants reveals structure-function relationships and physiological tradeoffs
Authors:Anthony L. Shiver  Hendrik Osadnik  Jason M. Peters  Rachel A. Mooney  Peter I. Wu  Kemardo K. Henry  Hannes Braberg  Nevan J. Krogan  James C. Hu  Robert Landick  Kerwyn Casey Huang  Carol A. Gross
Affiliation:1. Graduate Group in Biophysics, University of California San Francisco, San Francisco, CA 94158, USA;2. Department of Bioengineering, Stanford University School of Medicine, Stanford, CA 94305, USA;3. Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94158, USA;4. Department of Biochemistry, University of Wisconsin—Madison, Madison, WI 53706, USA;5. Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX 77843, USA;6. Department of Bacteriology, University of Wisconsin—Madison, Madison, WI 53706, USA;7. Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA 94158, USA;8. Quantitative Biosciences Institute, University of California San Francisco, San Francisco, CA 94158, USA;9. Gladstone Institutes, San Francisco, CA 94158, USA;10. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA;11. Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA;12. Chan Zuckerberg Biohub, San Francisco, CA 94158, USA;13. Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA 94158, USA;14. California Institute of Quantitative Biology, University of California San Francisco, San Francisco, CA 94158, USA
Abstract:
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