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Balancing cohesin eviction and retention prevents aberrant chromosomal interactions,Polycomb-mediated repression,and X-inactivation
Authors:Andrea J Kriz  David Colognori  Hongjae Sunwoo  Behnam Nabet  Jeannie T Lee
Institution:1. Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA;2. Department of Genetics, Harvard Medical School, Boston, MA 02114, USA;3. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA;4. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA
Abstract:
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  • Keywords:cohesin  WAPL  X chromosome inactivation  compartments  chromosome conformation  Xist RNA  nuclear organization  Polycomb complexes  chromatin loops  superstructures
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