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PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation
Authors:Yuqian Shen  Zi Chao Zhang  Shanshan Cheng  An Liu  Jian Zuo  Shuting Xia  Xian Liu  Wenhua Liu  Zhengping Jia  Wei Xie  Junhai Han
Institution:1. School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China;2. Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu 226001, China;3. Institute of Neuroscience, Soochow University, Suzhou 215000, China;4. Neurosciences and Mental Health Program, Hospital for Sick Children, University of Toronto, Toronto, ON M5S 1A1, Canada;5. Department of Neurology, Affiliated ZhongDa Hospital, Institute of Neuropsychiatry, Southeast University, Nanjing, Jiangsu 210009, China
Abstract:
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  • Keywords:PQBP1  translational elongation  eEF2  phosphorylation  mGluR-LTD  Renpenning syndrome  spatial recognition  novel object recognition  protein synthesis
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