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Immune-regulated IDO1-dependent tryptophan metabolism is source of one-carbon units for pancreatic cancer and stellate cells |
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| Authors: | Alice Clare Newman Mattia Falcone Alejandro Huerta Uribe Tong Zhang Dimitris Athineos Matthias Pietzke Alexei Vazquez Karen Blyth Oliver David Kenneth Maddocks |
| Institution: | 1. Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Switchback Road, Glasgow G61 1QH, UK;2. Cancer Research UK Beatson Institute, Switchback Road, Glasgow G61 1BD, UK |
| Abstract: |  |
| Keywords: | cancer metabolism one-carbon metabolism tryptophan serine IDO1 formate tumor microenvironment immunometabolism cancer immunology IFNγ PDAC stellate cells pancreas epacadostat immunotherapy |
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