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Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression
Authors:Thijmen van Vliet  Marta Varela-Eirin  Boshi Wang  Michela Borghesan  Simone M. Brandenburg  Rossana Franzin  Konstantinos Evangelou  Marc Seelen  Vassilis Gorgoulis  Marco Demaria
Affiliation:1. European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, Groningen, 9713 AV, the Netherlands;2. Experimental Nephrology Department, University Medical Center Groningen, University of Groningen, Groningen, 9713 GZ, the Netherlands;3. Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens 157 72, Greece;4. Faculty Institute for Cancer Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester M13 9NQ, UK;5. Biomedical Research Foundation, Academy of Athens, Athens 115 27, Greece;6. Center for New Biotechnologies and Precision Medicine, Medical School, National and Kapodistrian University of Athens, Athens 157 72, Greece
Abstract:
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  • Keywords:oxygen  senescence  SASP  aging  hypoxia  p16  hypoxia mimetics
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