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TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation
Authors:Katharina Fitzian  Anne Brückner  Laura Brohée  Reinhard Zech  Claudia Antoni  Stephan Kiontke  Raphael Gasper  Anna Livia Linard Matos  Stephanie Beel  Sabine Wilhelm  Volker Gerke  Christian Ungermann  Mark Nellist  Stefan Raunser  Constantinos Demetriades  Andrea Oeckinghaus  Daniel Kümmel
Institution:1. University of Münster, Institute of Biochemistry, 48149 Münster, Germany;2. University of Münster, Institute of Molecular Tumor Biology, 48149 Münster, Germany;3. Max Planck Institute for Biology of Ageing (MPI-AGE), 50931 Cologne, Germany;4. University of Osnabrück, Department of Biology/Chemistry, Structural Biology Section, 49076 Osnabrück, Germany;5. Max Planck Institute of Molecular Physiology, Department of Structural Biochemistry, 44227 Dortmund, Germany;6. Philipps-University Marburg, Faculty of Biology, Department of Plant Physiology and Photobiology, 35032 Marburg, Germany;7. Max Planck Institute of Molecular Physiology, Crystallography and Biophysics Unit, 44227 Dortmund, Germany;8. University of Münster, Institute of Medical Biochemistry, ZMBE, 48149 Münster, Germany;9. University of Osnabrück, Department of Biology/Chemistry, Biochemistry Section & Center of Cellular Nanoanalytics (CellNanOs), 49076 Osnabrück, Germany;10. Department of Clinical Genetics, Erasmus Medical Center, 3015 CN Rotterdam, the Netherlands;11. University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), 50931 Cologne, Germany
Abstract:
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  • Keywords:X-ray crystallography  TSC  membrane binding  phosphatidylinositol phosphate  mTORC1  lysosomes
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